上皮科学

Our commitment to the 严重的 asthma community and expanding scientific knowledge around the drivers and biological mechanisms of asthma

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遵循科学来改善病人的治疗效果

Severe asthma is a debilitating disease that affects up to 26 million people worldwide, resulting in frequent exacerbations and significant limitations on lung function and quality of life. We know that many people with asthma are underserved today and that asthma remains a significant public, 和个人, 健康的挑战.

Managing 严重的 asthma is challenging because airway inflammation is complex, 异质性和动态性. Patients often present with more than one type of inflammation, complicating their treatment.

Despite treatment advancements and increased scientific understanding over the last two decades, there remains vast potential to improve treatment particularly for patients with unknown, 不清楚, 或者炎症的多种驱动因素. That’s why our scientists are working to further expand scientific knowledge around the drivers and biological mechanisms of asthma to tackle the disease pathophysiology in new and powerful ways.

在澳门葡京网赌游戏, we’re building on our 50-year heritage in respiratory care by pursuing scientific breakthroughs that will revolutionise our understanding of the pathophysiology of asthma and inform the development of much-needed innovation that could improve patient care and outcomes.

We’re developing new ways of bringing treatments forward. This includes new drug modalities beyond the inhaled and biologic medicines of today, 让所有目标都能被消灭. Bringing precision medicine capabilities to identify the patients that respond and creating the next generation clinical trials which leverage technology to ease the burden on patients.

玛丽亚Belvisi Senior Vice President and Head of Research and Early Development, 呼吸 & 免疫学，澳门葡京赌博游戏R&D、澳门葡京网赌游戏

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Epithelial science is a new frontier in asthma research, and as pioneers in asthma we’re working to better characterise the key role of the airway epithelium and epithelial cytokines – such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33 and IL-25 – in triggering inflammation in asthma.

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By understanding the role key epithelial cytokines play at the top of the inflammatory cascade, we can begin to further understand the complex nature of this challenging disease.

Visit the Role of Epithelium in Severe Asthma website

科学深潜:推进上皮科学

What role does the airway epithelium play in 严重的 asthma?

Why is epithelial science a new frontier in asthma research?

"We remain committed to advancing the science so that people living with 严重的 asthma 谁 are underserved today will have a better future tomorrow. That’s why we are focused on following the science to understand the underlying causes and biological mechanisms of this debilitating disease.

Caterina Brindicci Senior Vice President and Global Head of 呼吸 & 免疫学 Late-Stage Development, 澳门葡京赌博游戏 R&D、澳门葡京网赌游戏

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向澳门葡京赌博游戏的专家学习

参考文献

1. 全球哮喘网络. 2022年全球哮喘报告.

2. 钟,KF.等。. International ERS/ATS guidelines on definition, evaluation and treatment of 严重的 asthma. Eur呼吸器. 2014年2月,43 (2):343 - 73.

3. 那些哮喘. 可在:http://www.谁.int /新闻/说明书/细节/哮喘. 2023年4月生效.

4. 文策尔年代. 成人严重哮喘. 我是急救医生吗. 2005; 172: 149-160.

5. Hyland ME, Masoli M, Lanario JW，等. 对无反应的可能解释, Responders and Super-responders to Biologics in Severe Asthma. 探索性假说医学. 2019; 4:35–38. 

6. 陈国平，蔡格尔，彼得斯，等. 异位重叠, 嗜酸性, and TH2-high asthma phenotypes in a general population with current asthma. 安过敏哮喘免疫. 2016; r116:37–42.  

7. Godar M, Blanchetot C, de Haard H，等. Personalized medicine with biologics for 严重的 type 2 asthma: current status and future prospects. 马伯. 2018; 10 (1): 34‐45.  

8. Amaral等人. Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007-2012. 临床反式过敏. 2018年5月4日8:13. 

9. 张建军，张建军，张建军，等. Uncontrolled asthma: a review of the prevalence, disease burden and options for treatment. 和地中海. 2006: 100: 1139-51.

10. Fernandes AG, Souza-Machado C, Coelho RC，等. Risk factors for death in patients with 严重的 asthma. [J]. 2014; 40 (4): 364-372.

11. 陈思，等. 系统的临床文献综述, 人文主义的, and economic burden associated with asthma uncontrolled by GINA Steps 4 or 5 treatment. 当前医学研究意见. 2018; 34: 2075-2088.

12. Roan F, Obata-Ninomiya K, Ziegler SF. Epithelial cell-derived cytokines: more than just signaling the alarm. J临床投资. 2019;129(4):1441-1451.